Preheat your oven to 350°F.
In a large bowl, combine ground beef, breadcrumbs, chopped onion, milk, brown sugar, ketchup, egg, salt, black pepper, garlic powder, and Worcestershire sauce. Mix until all ingredients are well combined.
Transfer the meat mixture into a loaf pan and shape it into a loaf.
In a small bowl, mix together the ketchup and brown sugar for the glaze. Spread the glaze evenly over the top of the meatloaf.
Bake in the preheated oven for 1 hour, or until the internal temperature reaches 160°F.
Let the meatloaf rest for 10 minutes before slicing and serving.