Preheat the Oven
Preheat your oven to 375°F (190°C).
Prepare the Chicken
Pat the chicken breasts dry with paper towels and season both sides with salt and pepper.
Make the Creamy Topping
In a mixing bowl, combine mayonnaise, sour cream, Parmesan cheese, garlic powder, onion powder, paprika, and Italian seasoning. Mix until smooth.
Assemble the Dish
Place the chicken breasts in a greased baking dish in a single layer. Spread the creamy topping evenly over each chicken breast.
Bake the Chicken
Bake in the preheated oven for 25–30 minutes, or until the chicken reaches an internal temperature of 165°F (74°C).
For a golden, bubbly topping, broil the chicken for the last 2–3 minutes.
Serve and Enjoy
Let the chicken rest for 5 minutes before serving. Garnish with fresh parsley or extra Parmesan if desired.